California Initiative to Advance Precision Medicine External Funding Opportunities

The purpose of this funding opportunity announcement (FOA) is to create a clinical consortium to recruit a cohort of early pubertal youth at risk for developing type 2 diabetes and study them through puberty. The ultimate goal of this undertaking will be to 1) develop more precise prediction of which individuals are truly at risk for developing youth-onset T2D and identify determinants of progression from prediabetes to T2D so that, ultimately, targeted prevention approaches can be developed and tested; and 2) increase understanding of the physiologic drivers of youth-onset T2D to guide development of more effective strategies to achieve glycemic control and preserve beta cell function.

The purpose of this FOA from the Food & Drug Administration is to fund COVID research that will strengthen and advance research in minority health and healthy equity, increase understanding of health disparities, and provide future direction for research that will contribute to regulatory decision making.

This National Science Foundation initiative calls for fundamentally new approaches in molecular sciences to drive new directions in biotechnology, a critical and emerging technology of the 21st century. This is the second year of a campaign targeting broad annual themes to be pursued through collaborative high risk/high reward projects. This year's solicitation calls for synergistic scientific research collaborations that involve innovative machine learning (ML) methods to foster advances in research on the function of biomolecular systems and have the potential to drive innovation in biotechnology.

This FOA solicits applications for U01 cooperative agreement research projects addressing the areas outlined above. The proposed projects should use a combination of state-of-the-art high throughput informatic and experimental approaches to: characterize and validate novel cancer targets; develop precise perturbagens that can affect the proposed targets of cancer treatments and define the mechanism(s) of action; identify molecular markers that can meaningfully predict responses or resistance to anticancer therapies and develop algorithms that can be applied to predict responses to treatments and/or define more precise treatment modalities.

The goal of this funding opportunity is to solicit Analgesic Development R61 applicants that propose 2-year exploratory/planning awards that are expected to enable a future application for RFA-NS-21-015 HEAL Initiative: Team Research – for Initial Translational Efforts in Non-addictive Analgesic Development. The application must include a plan for developing a strong research team, as well as a strategy to collect preliminary data linking putative therapeutic targets to the proposed pain indication.

This funding opportunity seeks applicants for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation of cells and networks to enable transformative understanding of dynamic signaling in the central nervous system. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the central nervous system.

This FOA encourages studies that develop and test the effectiveness of strategies for implementation and sustainable delivery of evidence-based mental health treatments and services to improve mental health outcomes for underserved populations in low-resourced settings in the United States.

The purpose of this FOA is to encourage research applications to develop and test the effectiveness of family navigator models designed to promote early access, engagement, coordination and optimization of mental health treatment and services for children and adolescents who are experiencing early symptoms of mental health problems. Applicants are required to develop and test the navigator model's ability to promote early access, engagement, coordination and optimization of mental health treatment and services for children and adolescents as soon as symptoms are detected. Applicants are also required to identify and test components of navigator models that drive improvements in mental health care; detect and interrogate tailoring variables that optimize the 'personalized match' between the unique mental health needs of youth to the appropriate level of intensity and frequency of mental health services; and utilize emerging novel technologies to track and monitor the trajectory of clinical, functional and behavioral progress toward achieving intended services outcomes.