California Initiative to Advance Precision Medicine External Funding Opportunities

This NIH Common Fund initiative solicits applications supporting collaborative investigative teams or individual scientists who propose unusually innovative research projects which, if successful, would have a major impact in developing, implementing, or disseminating innovative and effective interventions to prevent, reduce, or eliminate health disparities and advance health equity.

This Funding Opportunity Announcement invites applications to address health equity, drug costs, and access to new therapeutics or repurposed drugs for Alzheimer's disease and related dementias (AD/ADRD). Successful applications will seek to identify preferences for pharmacological treatment or cost barriers to treatment among racial and ethnic minority people living with AD/ADRD, and quantify expenditures and health-related quality of life among people interested in receiving novel or repurposed drugs for AD/ADRD.

Proposed U01 projects should use a combination of state-of-the-art high throughput informatic and experimental approaches to: characterize and validate novel cancer targets; develop precise perturbagens that can affect the proposed targets of cancer treatments and define the mechanism(s) of action; identify molecular markers that can meaningfully predict responses or resistance to anticancer therapies and develop algorithms that can predict responses to treatments and/or define more precise treatment modalities.

The goal of this funding opportunity is to solicit Analgesic Development R61 applicants that propose 2-year exploratory/planning awards that are expected to enable a future application for RFA-NS-21-015 HEAL Initiative: Team Research – for Initial Translational Efforts in Non-addictive Analgesic Development. The application must include a plan for developing a strong research team, as well as a strategy to collect preliminary data linking putative therapeutic targets to the proposed pain indication.

This funding opportunity seeks applicants for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation of cells and networks to enable transformative understanding of dynamic signaling in the central nervous system. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the central nervous system.

This FOA encourages studies that develop and test the effectiveness of strategies for implementation and sustainable delivery of evidence-based mental health treatments and services to improve mental health outcomes for underserved populations in low-resourced settings in the United States.

This FOA encourages research applications to develop and test the effectiveness of family navigator models designed to promote efficient optimization of mental health treatment for children and adolescents experiencing early symptoms of mental health problems.

This initiative will support collaborative, multi-disciplinary research on the adaptation, integration, and implementation of recommended guidelines of care of persons with multiple chronic conditions from populations that experience health disparities. Projects would be expected to involve more than one component and/or more than one level of influence within existing or newly proposed health care models.

The purpose of this Funding Opportunity Announcement is to support new investigators from diverse backgrounds, including from groups nationally underrepresented in biomedical, clinical, behavioral and social sciences research. Selected investigators will conduct small research projects in the scientific mission areas of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Human Genome Research Institute.

This Funding Opportunity Announcement supports pilot work for future studies testing the effectiveness of strategies to deliver evidence-based mental health services, treatment interventions, and/or preventive interventions in low-resourced mental health settings within the United States.