California Initiative to Advance Precision Medicine Demonstration Projects

CIAPM's portfolio of demonstration projects comprises broad collaborative efforts across institutions and sectors. The activities range from discovery to clinical implementation, aiming to enable more precise, individually targeted prevention, diagnosis, and treatment of disease, and to illustrate that precision medicine is making a difference now.

The pursuit of precision medicine is an inherently collaborative effort, requiring access to large data sets and to diverse technologies and expertise. One of the major goals of the California Initiative to Advance Precision Medicine is to foster such collaborations by supporting demonstration projects that leverage the State's expansive and diverse research and clinical expertise and other resources from public and private partners, including high tech capabilities and patient engagement efforts.

Current Projects

Adverse Childhood Experiences

CIAPM has awarded over $20 million to seven projects to address the health impacts of Adverse Childhood Experiences through a collaborative precision medicine approach.

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Improving Breast Cancer in Latinas: A Multi-Tiered Approach

This project aims to better understand the role of genetics in Latinas who develop breast cancer, and to increase community awareness of hereditary cancer risk and genetic testing.

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Integrated Machine-Learning Platform to Inform Precision Therapy in Breast Cancer Patients

This project applies precision medicine genomic profiling to find new treatments and to better match certain kinds of breast tumors to cancer existing therapies.

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Reducing Cancer Disparities Through Innovative Community-Academic Partnerships

The objective of this project is to develop, implement, and evaluate a Community Health Worker approach to cancer care that increases access to precision medicine at every stage of treatment.

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Completed Projects

Artificial Intelligence for Imaging of Brain Emergencies

This project successfully used artificial intelligence to automate brain scan evaluation.

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Early Prediction of Major Adverse Cardiovascular Events Using Remote Monitoring

This project monitored several types of patient data, including information from wearable health devices, to better predict who may be about to have a heart attack or stroke.

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Early Prostate Cancer: Predicting Treatment Response

This project focused on improving predictions about what treatment would work best for patients with early stage prostate cancer.

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Full Genome Analysis to Guide Precision Medicine

This project created a method that more thoroughly reads the entire human genome than all other available techniques.

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Precision Medicine for Multiple Sclerosis: Making it Work

This project developed an interactive digital tool to guide treatment decisions for multiple sclerosis patients that aligned with their experience, preferences, and priorities.

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Personal Mobile and Contextual Precision Health

This project developed a mobile health application to collect patient-reported data about blood pressure, mood, movement, and medication adherence.

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Precision Diagnosis of Acute Infectious Diseases

This project prepared a new method of infectious disease testing for use in clinical laboratories.

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California Kids Cancer Comparison

This project improved pediatric cancer care with novel, RNA-based treatment approaches; and by using large data sets to compare tumors between patients.

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Evaluations Report

A thorough, scientific review of CIAPM's first eight projects from a panel of experts.

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RFP Documents

Adverse Childhood Experiences (December 2019)

Adverse Childhood Experiences (December 2019)

Proposal submission guidelines

Cancer Disparities (July 2018)

Cancer Disparities (July 2018)

RFP review process

For More Information

Shannon Muir, PhD

Shannon Muir is a Co-Director of the California Initiative to Advance Precision Medicine.

shannon.muir@opr.ca.gov